Two years after the events of the Fourth Great Ninja War, the moon that Hagoromo Otsutsuki created long ago to seal away the Gedo Statue begins to descend towards the world, threatening to become a meteor that would destroy everything on impact. Amidst this crisis, a direct descendant of Kaguya Otsutsuki named Toneri Otsutsuki attempts to kidnap Hinata Hyuga but ends up abducting her younger sister Hanabi. Naruto and his allies now mount a rescue mission before finding themselves embroiled in a final battle to decide the fate of everything.
12-year-old Oriko Seki, who lost her parents in a car accident, ended up living in her grandmother's Onsen Ryokan Haru no Ya. With the ghost Uribou cohabitating with her and all the other odds, she ended up training to be a young female innkeeper. At first, she didn't like the training, but gradually felt her admiration for her title and began to train seriously. Thus, the growth of the young warrior Oriko begins.