Just days before Rhett (Chris Pine) is leaving for Nashville to pursue a lifelong dream of being a singer/songwriter, his girlfriend Samantha (Bre Blair) realizes that his future may not be their future. This news comes as a shock to Rhett, and he is faced with having to choose between following his dream and staying in his hometown in order to be with the woman he loves.
Though a childhood bout with polio left him dependent on an iron lung, Mark O'Brien (John Hawkes) maintains a career as a journalist and poet. A writing assignment dealing with sex and the disabled piques Mark's curiosity, and he decides to investigate the possibility of experiencing sex himself. When his overtures toward a caregiver scare her away, he books an appointment with sex surrogate Cheryl Green (Helen Hunt) to lose his virginity.
Newly widowed Frank Fogle embarks on a journey to Ireland to scatter his late wife’s ashes. His estranged son, Sean, recently released from prison, agrees to join only when his father promises that they’ll never see each other again following the trip. After revelations surface about an old flame of Frank’s wife and a charming hitchhiker with plans of her own intervenes, father and son find themselves drawn together in unexpected ways.
A down-on-his-luck crab fisherman embarks on a journey to get a young man with Down syndrome to a professional wrestling school in rural North Carolina and away from the retirement home where he’s lived for the past two and a half years.