Hotel night clerk Bart Bromley is a highly intelligent young man on the Autism spectrum. When a woman is murdered during his shift, Bart becomes the prime suspect. As the police investigation closes in, Bart makes a personal connection with a beautiful guest named Andrea, but soon realises he must stop the real murderer before she becomes the next victim.
Though a childhood bout with polio left him dependent on an iron lung, Mark O'Brien (John Hawkes) maintains a career as a journalist and poet. A writing assignment dealing with sex and the disabled piques Mark's curiosity, and he decides to investigate the possibility of experiencing sex himself. When his overtures toward a caregiver scare her away, he books an appointment with sex surrogate Cheryl Green (Helen Hunt) to lose his virginity.
TV weatherman Bill Harding is trying to get his tornado-hunter wife, Jo, to sign divorce papers so he can marry his girlfriend Melissa. But Mother Nature, in the form of a series of intense storms sweeping across Oklahoma, has other plans. Soon the three have joined the team of stormchasers as they attempt to insert a revolutionary measuring device into the very heart of several extremely violent tornados.
New York City. Melvin Udall, a cranky, bigoted, obsessive-compulsive writer, finds his life turned upside down when neighboring gay artist Simon is hospitalized and his dog is entrusted to Melvin. In addition, Carol, the only waitress who will tolerate him, must leave work to care for her sick son, making it impossible for Melvin to eat breakfast.
Advertising executive Nick Marshall is as cocky as they come, but what happens to a chauvinistic guy when he can suddenly hear what women are thinking? Nick gets passed over for a promotion, but after an accident enables him to hear women's thoughts, he puts his newfound talent to work against Darcy, his new boss, who seems to be infatuated with him.