A fanatical animal rights activist releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger feeds experimental steroids to wild alligators so they can fight back. The giant pythons and gargantuan alligators go on a killing spree, and it is now left up to the two feuding women to put aside their differences to put a stop to the creatures and the destruction.
When another Mega Shark returns from the depths of the sea, world militaries go on high alert. Ocean traffic grinds to a standstill as everyone lives in fear of the insatiable beast. Out of options, the US government unleashes the top secret Mecha Shark project -- a mechanical shark built to have the same exact characteristics as Mega. A pair of scientists pilot the mechanical creature as they fight Mega in a pitched battle to save the planet. But when faulty mechanics cause the Mecha to go after humans, the scientists must somehow guide Mega to Mecha in hopes that the two titans will kill each other - or risk untold worldwide destruction.
Debbie Taylor is a former 1980s pop star bent on making a comeback and returning to the Billboard charts. As she prepares to once again take the music industry by storm, Debbie's record label deems her irrelevant and abruptly drops her. Out of money, she leaves the fast lane of New York to move in with her sister in Youngstown, Ohio.