As a corporate auditor who works in a number of different offices, Jonathan McQuarry wanders without an anchor among New York's power brokers. A chance meeting with charismatic lawyer Wyatt Bose leads to Jonathan's introduction to The List, an underground sex club. Jonathan begins an affair with a woman known only as S, who introduces Jonathan to a world of treachery and murder.
Carla and Marco are manic-depressive poets whose art is fueled by their emotional extremes. When they go off their meds, they end up in the same psychiatric hospital. As the chemistry between them stirs up their emotions, it intensifies their mania. Despite doctors' and parents' attempts to separate them, they pursue their beautiful but destructive romance which swings them from fantastical manic highs to suicidal depressive lows, until they have to choose between sanity and love.